[Peculiarity of reassortment of current wild type influenza viruses with master donor viruses for live influenza vaccine].
Identifieur interne : 002D97 ( Main/Exploration ); précédent : 002D96; suivant : 002D98[Peculiarity of reassortment of current wild type influenza viruses with master donor viruses for live influenza vaccine].
Auteurs : I V Kiseleva ; E A Bazhenova ; N V Larionova ; E A Fedorova ; I A Dubrovina ; I N Isakova-Sivak ; L G RudenkoSource :
- Voprosy virusologii [ 0507-4088 ]
Descripteurs français
- KwdFr :
- Adaptation biologique, Basse température, Glycoprotéine hémagglutinine du virus influenza (génétique), Glycoprotéine hémagglutinine du virus influenza (immunologie), Grippe humaine (), Grippe humaine (immunologie), Grippe humaine (virologie), Gènes viraux, Génotype, Humains, Liaison génétique, Russie, Réplication virale, Sialidase (génétique), Sialidase (immunologie), Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (immunologie), Sous-type H5N1 du virus de la grippe A (génétique), Sous-type H5N1 du virus de la grippe A (immunologie), Vaccins antigrippaux (génétique), Vaccins antigrippaux (immunologie), Vaccins atténués, Virus recombinants (génétique), Virus recombinants (immunologie).
- MESH :
- génétique : Glycoprotéine hémagglutinine du virus influenza, Sialidase, Sous-type H2N2 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A, Vaccins antigrippaux, Virus recombinants.
- immunologie : Glycoprotéine hémagglutinine du virus influenza, Grippe humaine, Sialidase, Sous-type H2N2 du virus de la grippe A, Sous-type H5N1 du virus de la grippe A, Vaccins antigrippaux, Virus recombinants.
- virologie : Grippe humaine.
- Adaptation biologique, Basse température, Grippe humaine, Gènes viraux, Génotype, Humains, Liaison génétique, Russie, Réplication virale, Vaccins atténués.
English descriptors
- KwdEn :
- Adaptation, Biological, Cold Temperature, Genes, Viral, Genetic Linkage, Genotype, Hemagglutinin Glycoproteins, Influenza Virus (genetics), Hemagglutinin Glycoproteins, Influenza Virus (immunology), Humans, Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (immunology), Influenza A Virus, H5N1 Subtype (genetics), Influenza A Virus, H5N1 Subtype (immunology), Influenza Vaccines (genetics), Influenza Vaccines (immunology), Influenza, Human (immunology), Influenza, Human (prevention & control), Influenza, Human (virology), Neuraminidase (genetics), Neuraminidase (immunology), Reassortant Viruses (genetics), Reassortant Viruses (immunology), Russia, Vaccines, Attenuated, Virus Replication.
- MESH :
- chemical , genetics : Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines, Neuraminidase.
- chemical , immunology : Hemagglutinin Glycoproteins, Influenza Virus, Influenza Vaccines, Neuraminidase.
- geographic : Russia, Vaccines, Attenuated.
- genetics : Influenza A Virus, H2N2 Subtype, Influenza A Virus, H5N1 Subtype, Reassortant Viruses.
- immunology : Influenza A Virus, H2N2 Subtype, Influenza A Virus, H5N1 Subtype, Influenza, Human, Reassortant Viruses.
- prevention & control : Influenza, Human.
- virology : Influenza, Human.
- Adaptation, Biological, Cold Temperature, Genes, Viral, Genetic Linkage, Genotype, Humans, Virus Replication.
Abstract
The live attenuated influenza vaccine (LAIV) currently licensed in Russia consists of the reassortant viruses with hemagglutinin (HA) and neuraminidase (NA) gene segments from the circulating wild-type viruses and the six internal protein-encoding gene segments from cold-adapted master donor viruses (MDV) A/Leningrad/134/17/57 (H2N2) or B/USSR/60/69. Presently, only classical reassortment technique is approved for the generation of Russian LAIV strains. In this work, we describe the obstacles to the development of LAIV 6:2 vaccine strains depending on the phenotypic properties of the wild-type viruses used for reassortment. It was demonstrated that the highest percentage of 6:2 vaccine reassortants could be achieved when wild-type parental viruses were resistant to non-specific gamma-inhibitors. It was shown that it was impossible to generate 6:2 vaccine reassortants possessing six internal genes of the AILeningrad113417/57 (H2N2) master donor virus and avian HA and NA genes from H5N1-PR8 viruses using classical reassortment technique. It was suggested that strong constellation effects between the gene segments of the parental viruses could affect the virus gene reassortment. A strong interaction between the genome segments encoding neuraminidase of avian origin and PB2 gene of PR8 virus was observed. When the PB2 gene was inherited from cold-adapted master donor virus, the neuraminidase was also found to be of MDV origin.
PubMed: 24640168
Affiliations:
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Le document en format XML
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last="Fedorova">E A Fedorova</name></author><author><name sortKey="Dubrovina, I A" sort="Dubrovina, I A" uniqKey="Dubrovina I" first="I A" last="Dubrovina">I A Dubrovina</name></author><author><name sortKey="Isakova Sivak, I N" sort="Isakova Sivak, I N" uniqKey="Isakova Sivak I" first="I N" last="Isakova-Sivak">I N Isakova-Sivak</name></author><author><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L G" last="Rudenko">L G Rudenko</name></author></analytic><series><title level="j">Voprosy virusologii</title><idno type="ISSN">0507-4088</idno></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adaptation, Biological</term><term>Cold Temperature</term><term>Genes, Viral</term><term>Genetic Linkage</term><term>Genotype</term><term>Hemagglutinin Glycoproteins, Influenza Virus (genetics)</term><term>Hemagglutinin Glycoproteins, Influenza Virus (immunology)</term><term>Humans</term><term>Influenza A Virus, H2N2 Subtype (genetics)</term><term>Influenza A Virus, H2N2 Subtype (immunology)</term><term>Influenza A Virus, H5N1 Subtype (genetics)</term><term>Influenza A Virus, H5N1 Subtype (immunology)</term><term>Influenza Vaccines (genetics)</term><term>Influenza Vaccines (immunology)</term><term>Influenza, Human (immunology)</term><term>Influenza, Human (prevention & control)</term><term>Influenza, Human (virology)</term><term>Neuraminidase (genetics)</term><term>Neuraminidase (immunology)</term><term>Reassortant Viruses (genetics)</term><term>Reassortant Viruses (immunology)</term><term>Russia</term><term>Vaccines, Attenuated</term><term>Virus Replication</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Adaptation biologique</term><term>Basse température</term><term>Glycoprotéine hémagglutinine du virus influenza (génétique)</term><term>Glycoprotéine hémagglutinine du virus influenza (immunologie)</term><term>Grippe humaine ()</term><term>Grippe humaine 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grippe A</term><term>Sous-type H5N1 du virus de la grippe A</term><term>Vaccins antigrippaux</term><term>Virus recombinants</term></keywords><keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H2N2 Subtype</term><term>Influenza A Virus, H5N1 Subtype</term><term>Influenza, Human</term><term>Reassortant Viruses</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term></keywords><keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adaptation, Biological</term><term>Cold Temperature</term><term>Genes, Viral</term><term>Genetic Linkage</term><term>Genotype</term><term>Humans</term><term>Virus Replication</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Adaptation biologique</term><term>Basse température</term><term>Grippe humaine</term><term>Gènes viraux</term><term>Génotype</term><term>Humains</term><term>Liaison génétique</term><term>Russie</term><term>Réplication virale</term><term>Vaccins atténués</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The live attenuated influenza vaccine (LAIV) currently licensed in Russia consists of the reassortant viruses with hemagglutinin (HA) and neuraminidase (NA) gene segments from the circulating wild-type viruses and the six internal protein-encoding gene segments from cold-adapted master donor viruses (MDV) A/Leningrad/134/17/57 (H2N2) or B/USSR/60/69. Presently, only classical reassortment technique is approved for the generation of Russian LAIV strains. In this work, we describe the obstacles to the development of LAIV 6:2 vaccine strains depending on the phenotypic properties of the wild-type viruses used for reassortment. It was demonstrated that the highest percentage of 6:2 vaccine reassortants could be achieved when wild-type parental viruses were resistant to non-specific gamma-inhibitors. It was shown that it was impossible to generate 6:2 vaccine reassortants possessing six internal genes of the AILeningrad113417/57 (H2N2) master donor virus and avian HA and NA genes from H5N1-PR8 viruses using classical reassortment technique. It was suggested that strong constellation effects between the gene segments of the parental viruses could affect the virus gene reassortment. A strong interaction between the genome segments encoding neuraminidase of avian origin and PB2 gene of PR8 virus was observed. When the PB2 gene was inherited from cold-adapted master donor virus, the neuraminidase was also found to be of MDV origin.</div></front></TEI><affiliations><list></list><tree><noCountry><name sortKey="Bazhenova, E A" sort="Bazhenova, E A" uniqKey="Bazhenova E" first="E A" last="Bazhenova">E A Bazhenova</name><name sortKey="Dubrovina, I A" sort="Dubrovina, I A" uniqKey="Dubrovina I" first="I A" last="Dubrovina">I A Dubrovina</name><name sortKey="Fedorova, E A" sort="Fedorova, E A" uniqKey="Fedorova E" first="E A" last="Fedorova">E A Fedorova</name><name sortKey="Isakova Sivak, I N" sort="Isakova Sivak, I N" uniqKey="Isakova Sivak I" first="I N" last="Isakova-Sivak">I N Isakova-Sivak</name><name sortKey="Kiseleva, I V" sort="Kiseleva, I V" uniqKey="Kiseleva I" first="I V" last="Kiseleva">I V Kiseleva</name><name sortKey="Larionova, N V" sort="Larionova, N V" uniqKey="Larionova N" first="N V" last="Larionova">N V Larionova</name><name sortKey="Rudenko, L G" sort="Rudenko, L G" uniqKey="Rudenko L" first="L G" last="Rudenko">L G Rudenko</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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